dr n. med. Agnieszka Surowiecka, prof. dr hab. n. med. Wioletta Barańska-Rybak
Key words: polinucleotides, biostimulation
Tissue biostimulation is a rapidly developing direction in anti-aging medicine. The selective action at the cellular and receptor levels makes modern skin regenerative products more effective with a lower risk of side effects. The purpose of this study was to discuss the mechanisms of action of long-chain polynucleotides contained in the Nucleofill® product (Promoitalia, Italy, distribution of Croma Pharma Polska S.p. z o.o.) and to present the collected own experiences. The product acts in three directions: receptor, stimulating fibroblasts to differentiate and produce proteins of the extracellular matrix, binding water in the deep layers of the dermis, ie. the „electrostatic sponge effect”, and antioxidant, consisting in the long-term capture of free radicals.