dr n. med. Lidia Majewska
Key words: MSC-derived exosomes, anti-aging, anti-inflammatory effects, immunomodulation, regenerative medicine
Exosomes are nanobubbles secreted by cells, serving as mediators for intercellular communication. Their unique contents consist of particles of nucleic acids, proteins and lipids, which reflect the characteristics of exo-forming cells. Exosomes derived from mesenchymal stem cells (MSC exosomes) have gained much interest due to their immunomodulatory and reewogenerative functions. Many studies have demonstrated the anti-inflammatory, anti-aging and wound healing stimulating effects of MSC exosomes in vitro and in vivo models. Advances in the field of exosome biology are likely to lead to their widespread clinical application, especially in oncological and neurodegenerative diseases.
This review is based on publications that describe the therapeutic potential of MSC exosomes and their mode of action in selected disease entities, including skin diseases. Attention is also given to the control measures required for the development and use of exosome-based therapies.